FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF REPAGLINIDE

Objective: The present study’s is to develop floating drug delivery system of repaglinide. Methods: Moringa gum, Repaglinide, HPMC K100M, Sodium alginate, Calcium Carbonate, Citrate. obtained formulation was evaluated for content, pH, in vitro gelling capacity, buoyancy studies, and dissolution studies. Results Discussion: All the total F1-F12 formulations showed pH ranging from 5.1 7.9, lag time 5 s 12 with greater than h, viscosity 619 3856 cp, content 31.2% 93.1%, percent release 78.9% 93.9%. Dissolution studies that F12 formulation-containing (30 mg) polymer (4000 93.9% h which said be optimized. Thus, best (F12) subjected a 3-month period stability found stable reported no significant change. Conclusion: goal evaluate situ gel forming solution repaglinide moringa gum as rate retardant polymer.